Journal Search Engine
Search Advanced Search Adode Reader(link)
Download PDF Export Citaion korean bibliography PMC previewer
ISSN : 1225-0082(Print)
ISSN : 2288-1905(Online)
The Medical Journal of Chosun University Vol.38 No.1 pp.36-39
DOI :

A Case of Multiple Recurrent Pulmonary Embolism on Aspirin

Soo Youn Lee*, Myung Joon Chae, Duck Hyun Jang, Yong Moo Rho
Department of Internal Medicine, Sejong General Hospital, Bucheon, South Korea.
(Received February 4, 2013; Accepted March 15, 2013)

Abstract

Pulmonary embolism (PE) still has a high associated mortality. Anticoagulation should be continued until the benefit ofpreventing recurrent PE is outweighed by the risks of bleeding. Furthermore, D-dimer values and residual clot burden maypredict recurrent thromboembolic events in patients that have completed anticoagulation therapy. The authors describe thecase of a 69-year-old female who suffered multiple recurrent PE on aspirin, her medical history included idiopathic PE, andshe had been on anticoagulant for a considerable time before switching to aspirin. It is important the possibility of recurrentPE be borne in mind to prevent secondary prevention, and that other treatment options be considered in cases of recurrentPE.

Reference

1.Torbicki A, Perrier A, Konstantinides S, Agnelli G, Galiè N, Pruszczyk P, Bengel F, Brady AJ, Ferreira D, Janssens U, et al. Guidelines on the diagnosis and management of acute pulmonary embolism. Eur Heart J 2008; 29: 2276-315.
2.East AT, Wakefield TW. What is the optimal duration of treatment for DVT? An update on evidence-based medicine of treatment for DVT. Semin Vasc Surg 2010; 23: 182-91.
3.Zhu T, Martinez I, Emmerich J. Venous thromboembolism: risk factors for recurrence. Arterioscler Thromb Vasc Biol 2009; 29: 298-310.
4.van Es J, Douma RA, Gerdes VE, Kamphuisen PW, Büller HR. Acute pulmonary embolism. Part 2: treatment Nat Rev Cardio 2010; 7: 613-22.
5.Liem TK, DeLoughery TG. First episode and recurrent venous thromboembolism: Who is identifiably at risk? Semin Vasc Surg 2008; 21: 132-38.
6.Goldhaber S. Thrombolysis for pulmonary embolism. N Engl J M 2002; 347: 1131-2.
7.Grifoni S, Olivotto I, Cecchini P, Pieralli F, Camaiti A, Santoro G, Conti A, Agnelli G, Berni G. Short-term clinical outcome of patients with acute pulmonary embolism, normal blood pressure, and echocardiographic right ventricular dysfunction. Circulation 2000; 101: 2817-22.
8.Fiumara K, Kucher N, Fanikos J, Goldhaber SZ. Predictors of major hemorrhage following fibrinolysis for acute pulmonary embolism. Am J Cardiol 2006; 97: 127-29.
9.Tan M, Mos IC, Klok FA, Huisman MV. Residual venous thrombosis as predictive factor for recurrent venous thromboembolism in patients with proximal deep vein thrombosis: a systematic review Br J Haematol 2011; 153: 168-78.
10.Collaborative overview of randomised trials of antiplatelet therapy--III: Reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients. Antiplatelet Trialists' Collaboration. BMJ 1994; 308: 235-46.
11.Prevention of pulmonary embolism and deep vein thrombosis with low dose aspirin: Pulmonary Embolism Prevention (PEP) trial. Lancet 2000; 355: 1295-302.
12.Becattini C, Agnelli G, Schenone A, Eichinger S, Bucherini E, Silingardi M, Bianchi M, Moia M, Ageno W, Vandelli MR, Grandone E, Prandoni P. Aspirin for preventing the recurrence of venous thromboembolism. N Engl J Med 2012 May 24; 366: 1959-67.