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ISSN : 1225-0082(Print)
ISSN : 2288-1905(Online)
The Medical Journal of Chosun University Vol.38 No.1 pp.20-22

De novo Acute Myeloid Leukemia with JAK2 V617F: A Case Report

Geon Park1,*, Woo Sung Kim1, Gyun Cheol Park1, Sung Ho Kang1, Chi Young Park2, Sook Jin Jang1,3, Dae Soo Moon1

1Department of Laboratory Medicine, 2Department of Internal Medicine,
3Research Center for Resistant Cells, College of Medicine, Chosun University
(Received December 26, 2012; Accepted March 15, 2013)


JAK2 V617F mutation is a common event in chronic myeloproliferative disorders. However, de novo acute myeloid leukemiawith JAK2 V617F is rarely encountered. The authors report the case of a 74-year-old male with de novo acute myeloblasticleukemia without maturation (AML M1) and a JAk2 V617F heterozygotic mutation. Despite treatment with standardAML regimens, the patient died 2 months after a diagnosis of acute leukemia. This case of an AML patient with a JAK2V617F mutation with a poor prognosis suggests that despite its rarity, a JAK2 V617F mutational study be considered forprognostic purposes in AML.



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