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ISSN : 1225-0082(Print)
ISSN : 2288-1905(Online)
The Medical Journal of Chosun University Vol.44 No.1 pp.66-69

Cold agglutinin disease associated lymphoproliferative disease

Hee-Jeong Lee,Sang-Gon Park,Chi Young Park
Corresponding author Chi Young Park Department of Internal Medicine, Hemato-oncology, Chosun University Hospital, 365 Pilmundaero, Dong-gu, Gwangju 61453, Korea Tel: +82-62-220-3279 Fax: +82-62-234-9653


Cold agglutinin disease (CAD) is a rare and poorly understood disorder affecting 15% of patients with autoimmune hemolytic anemia (AIHA). In this case report, we describe a case of CAD mistaken for liver cirrhosis. A 57-year-old male patient was presumptive diagnosed with early liver cirrhosis due to mild hyperbilirubinemia and abdominal sonography finding without other findings as thrombocytopenia or prothrombin time prolongation. After 3 month, the patient was referred to our hospital with agglutination of peripheral red blood cell at room temperature and livedo reticularis of the whole body and finally diagnosed with CAD associated B cell lymphoproliferative disorder.